Gene name:
Igsf1 (Kiaa0364) ;
Protein name:
Immunoglobulin superfamily member 1 (IgSF1) ;
Alternative:
Inhibin-binding protein (InhBP) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with INHA; the interaction is not confirmed by standard receptor binding assays (By similarity). Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A. Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B (By similarity). Interacts with HECTD1.
Function:
Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription.
Subcellular Location:
Isoform 5
Secreted
Protein Attributes:
50:
MMLRTFTLLL | LCIWLNPGMT | SLAVESQPEL | WIESNYPQAP | WENITLWCKS |
100:
PSRVSSKFLL | LKDNSQMTWI | RPPYKTFQVS | FFIGALTESN | TGLYRCCYWK |
150:
EKGWSKPSKI | LELEAPGQLP | KPIFWIQAET | PPLPGCNVNI | FCHGWLQDLV |
200:
FMLFKEGYTE | PVDYQVPTGT | MAIFSIDNLA | PENEGVYICR | THIQMLPTLW |
250:
SEPSNPLKLV | VAGLYPKPTL | TAHPGPILAP | GESLSLRCQG | PIYGMTFALM |
300:
RLEDLKKSFY | HKKPIKNEAY | FYFQDLKIQD | TGHYLCFYYD | GSYRGSLLSD |
350:
ILKIWVTDTF | PKTWLLVQPS | PVIQMGQNVS | LRCGGLMDGV | GLALYKKGEE |
400:
KPLQFLDASS | NTGNNSFFLK | NVTYRDAGIY | SCHYYLTWKT | SIKMATYNTV |
450:
ELMVVAWPSS | VFKVGKTITL | QCRVSHPVLE | FSLEWEERTT | FQKFSVDGDF |
500:
LITDIEGQGT | GTYSCSYRIE | AHPNTWSHRS | KPLKLVGPAG | FLTWNSILNE |
550:
AVRVSLTMQL | ASLLLLVVWI | RWKCRRLRLR | EAWLLGTAQG | VAMLFILMAL |
600:
LCCGLCNGAL | TEEIEIVMPT | PKPELWAETN | FPLAPWKNLT | LWCRSPSGST |
650:
KEFVLLKDGT | GWIATRPASE | QVRAAFPLGA | LTHSHTGSYH | CHSWEEMAVS |
700:
EPSEALELVG | TDILPKPVIS | ASLPIRGQEL | QIRCKGWLEG | LGFALYKKGE |
750:
QEPVQQLGAV | GREAFFTIQR | MEDKDEGNYS | CRTHTEMQPF | KWSEPSEPLE |
800:
LVIKEMYPKP | FFKTWASPVV | TPGSRVTFNC | STSHEHMSFI | LYKDGNEIAS |
850:
SDLAWGNPGG | STAHFLIISV | GIGDGGNYSC | RYYDFSIWSE | PSNPVELVVT |
900:
EFYPKPTLLA | QPGPVVLPGK | NVTLRCQGIF | QGMRFALLQE | GTHTPLQFQS |
950:
TSGTSADFLL | HTVGAQDFGN | YSCVYYETTM | SNRGSSLSTP | LMIWVTDTFP |
1000:
RPWLSAEPSS | VVTMGQNVTL | WCQGPVRGVG | YILHKEGEAT | SMQLWGSTSN |
1050:
EGAFPIINIS | GASIGRYSCC | YHPDWMSPIK | IQPSNTLELI | VTGLLPKPSL |
1100:
LVQPGPMVAP | GENVTLQCQG | ELPDSTFVLL | KEGTRQPLEQ | QRPSGYRADF |
1150:
WMPVVRDQDS | GVYSCVYYLD | SAPLVASNHS | NSLEIWVTDK | PPKPSLSAWP |
1200:
STIFKLGKDI | TLQCRGPLPG | VEFVLEHDGE | EAPQQFSEDG | DFVIDNLEGK |
1250:
GIGNYSCSYR | LQAYPDIWSE | PSDTLELVGA | AGPVAQECTV | GNIVRSTLIV |
1300:
VVVVALGIVL | AVEWKKWPRL | RTRGSETDGR | DQTVVLEECN | QEGEPGTTTN |
1317:
SPSSASQEVS | VELTVPI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse IgSF1
ELISA Kit for Mouse IgSF1
ELISA Kit for Mouse IgSF1
Polyclonal Antibody for Mouse IgSF1
Polyclonal Antibody for Mouse IgSF1
Polyclonal Antibody for Mouse IgSF1
Monoclonal Antibody for Mouse IgSF1
Monoclonal Antibody for Mouse IgSF1
Monoclonal Antibody for Mouse IgSF1
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5);DISRUPTION PHENOTYPE
tissue :
Pituitary .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
3.
"The transcriptional landscape of the mammalian genome."
Carninci P.
,
Kasukawa T.
,
Katayama S.
,
Gough J.
,
Frith M.C.
,
Maeda N.
,
Oyama R.
,
Ravasi T.
,
Lenhard B.
,
Wells C.
,
Kodzius R.
,
Shimokawa K.
,
Bajic V.B.
,
Brenner S.E.
,
Batalov S.
,
Forrest A.R.
,
Zavolan M.
,
Davis M.J.
,
Wilming L.G.
,
Aidinis V.
,
Allen J.E.
,
Ambesi-Impiombato A.
,
Apweiler R.
,
Aturaliya R.N.
,
Bailey T.L.
,
Bansal M.
,
Baxter L.
,
Beisel K.W.
,
Bersano T.
,
Bono H.
,
Chalk A.M.
,
Chiu K.P.
,
Choudhary V.
,
Christoffels A.
,
Clutterbuck D.R.
,
Crowe M.L.
,
Dalla E.
,
Dalrymple B.P.
,
de Bono B.
,
Della Gatta G.
,
di Bernardo D.
,
Down T.
,
Engstrom P.
,
Fagiolini M.
,
Faulkner G.
,
Fletcher C.F.
,
Fukushima T.
,
Furuno M.
,
Futaki S.
,
Gariboldi M.
,
Georgii-Hemming P.
,
Gingeras T.R.
,
Gojobori T.
,
Green R.E.
,
Gustincich S.
,
Harbers M.
,
Hayashi Y.
,
Hensch T.K.
,
Hirokawa N.
,
Hill D.
,
Huminiecki L.
,
Iacono M.
,
Ikeo K.
,
Iwama A.
,
Ishikawa T.
,
Jakt M.
,
Kanapin A.
,
Katoh M.
,
Kawasawa Y.
,
Kelso J.
,
Kitamura H.
,
Kitano H.
,
Kollias G.
,
Krishnan S.P.
,
Kruger A.
,
Kummerfeld S.K.
,
Kurochkin I.V.
,
Lareau L.F.
,
Lazarevic D.
,
Lipovich L.
,
Liu J.
,
Liuni S.
,
McWilliam S.
,
Madan Babu M.
,
Madera M.
,
Marchionni L.
,
Matsuda H.
,
Matsuzawa S.
,
Miki H.
,
Mignone F.
,
Miyake S.
,
Morris K.
,
Mottagui-Tabar S.
,
Mulder N.
,
Nakano N.
,
Nakauchi H.
,
Ng P.
,
Nilsson R.
,
Nishiguchi S.
,
Nishikawa S.
,
Nori F.
,
Ohara O.
,
Okazaki Y.
,
Orlando V.
,
Pang K.C.
,
Pavan W.J.
,
Pavesi G.
,
Pesole G.
,
Petrovsky N.
,
Piazza S.
,
Reed J.
,
Reid J.F.
,
Ring B.Z.
,
Ringwald M.
,
Rost B.
,
Ruan Y.
,
Salzberg S.L.
,
Sandelin A.
,
Schneider C.
,
Schoenbach C.
,
Sekiguchi K.
,
Semple C.A.
,
Seno S.
,
Sessa L.
,
Sheng Y.
,
Shibata Y.
,
Shimada H.
,
Shimada K.
,
Silva D.
,
Sinclair B.
,
Sperling S.
,
Stupka E.
,
Sugiura K.
,
Sultana R.
,
Takenaka Y.
,
Taki K.
,
Tammoja K.
,
Tan S.L.
,
Tang S.
,
Taylor M.S.
,
Tegner J.
,
Teichmann S.A.
,
Ueda H.R.
,
van Nimwegen E.
,
Verardo R.
,
Wei C.L.
,
Yagi K.
,
Yamanishi H.
,
Zabarovsky E.
,
Zhu S.
,
Zimmer A.
,
Hide W.
,
Bult C.
,
Grimmond S.M.
,
Teasdale R.D.
,
Liu E.T.
,
Brusic V.
,
Quackenbush J.
,
Wahlestedt C.
,
Mattick J.S.
,
Hume D.A.
,
Kai C.
,
Sasaki D.
,
Tomaru Y.
,
Fukuda S.
,
Kanamori-Katayama M.
,
Suzuki M.
,
Aoki J.
,
Arakawa T.
,
Iida J.
,
Imamura K.
,
Itoh M.
,
Kato T.
,
Kawaji H.
,
Kawagashira N.
,
Kawashima T.
,
Kojima M.
,
Kondo S.
,
Konno H.
,
Nakano K.
,
Ninomiya N.
,
Nishio T.
,
Okada M.
,
Plessy C.
,
Shibata K.
,
Shiraki T.
,
Suzuki S.
,
Tagami M.
,
Waki K.
,
Watahiki A.
,
Okamura-Oho Y.
,
Suzuki H.
,
Kawai J.
,
Hayashizaki Y.
more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
strain :
C57BL/6J .
tissue :
Pituitary .
4.
"Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement."
Sun Y.
,
Bak B.
,
Schoenmakers N.
,
van Trotsenburg A.S.
,
Oostdijk W.
,
Voshol P.
,
Cambridge E.
,
White J.K.
,
le Tissier P.
,
Gharavy S.N.
,
Martinez-Barbera J.P.
,
Stokvis-Brantsma W.H.
,
Vulsma T.
,
Kempers M.J.
,
Persani L.
,
Campi I.
,
Bonomi M.
,
Beck-Peccoz P.
,
Zhu H.
,
Davis T.M.
,
Hokken-Koelega A.C.
,
Del Blanco D.G.
,
Rangasami J.J.
,
Ruivenkamp C.A.
,
Laros J.F.
,
Kriek M.
,
Kant S.G.
,
Bosch C.A.
,
Biermasz N.R.
,
Appelman-Dijkstra N.M.
,
Corssmit E.P.
,
Hovens G.C.
,
Pereira A.M.
,
den Dunnen J.T.
,
Wade M.G.
,
Breuning M.H.
,
Hennekam R.C.
,
Chatterjee K.
,
Dattani M.T.
,
Wit J.M.
,
Bernard D.J.
more...
Nat. Genet.44:1375-1381(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE